Old Weird Scotland @WeirdScotland · Aug 25

Summer 1970: a rare form of typhoid is infecting people in Edinburgh. Dr Nancy Conn, a bacteriologist at Western General, finds the source and prevents a major outbreak with detective work and sanitary towels.

A thread on one of Scotland's unsung #WomenInSTEM

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Old Weird Scotland @WeirdScotland · Aug 25

Typhoid was and is uncommon in Scotland. Apart from an outbreak in Aberdeen in the 60s, most cases are linked to overseas travel. The Edinburgh outbreak was different. It was mainly children who were being infected, from different parts of the city. 1/n

Old Weird Scotland @WeirdScotland · Aug 25

None of them had ever been abroad and none had any link to India, where this rare strain of the Salmonella typhi bacterium comes from. Dr Conn sat with the patients and interviewed them in detail. Many were senseless with fever. She interviewed their friends and families too. 2/n

Old Weird Scotland @WeirdScotland · Aug 25

Only one thing seemed to link them-- they had all played, fished, or picnicked at the Water of Leith--some had drunk the water. Dr Conn mapped out where the patients had been, but it covered a sizable stretch of a fairly polluted river. 3/n https://t.co/H3PNEJPwvQ

Old Weird Scotland @WeirdScotland · Aug 25

Dr Conn set out to test the river water across the whole area the children had played. The standard protocol for collecting bacteria, known as Moore swabs, kept failing, got muddy and disintegrated in the fast, dirty river. Dr Conn made her own sturdy replacement samplers. 4/n https://t.co/u2u3wv62zw

Old Weird Scotland @WeirdScotland · Aug 25

The sanitary towels, after being sunk in the river, were taken back to the lab and cultured. Some had collected the bacterium. Just upstream from the first one that came back positive, Dr Conn found a surface water drain outlet. Problem is, typhoid shouldn't be in rain water. 5/n https://t.co/quiBZAFzno

Old Weird Scotland @WeirdScotland · Aug 25

The outlet drained rain and surface water from all of the north of Colinton. Dr Conn called the City Engineers. She gave them packs of Dr White's No. 1 sanitary towels and showed them how to use them. They put them down every drain and manhole north of the river to sample. 6/n

Old Weird Scotland @WeirdScotland · Aug 25

Like before in the river, Dr Conn cultured the samples in the lab and narrowed in on the source: one surface water drain that ran by one particular block of houses. The engineers dug up the road to investigate.

The number of typhoid cases was rising. 7/n https://t.co/qzSXCVuvCp

Old Weird Scotland @WeirdScotland · Aug 25

Sewer pipes are always installed below surface water drains for safety (in case the sewer leaks). When the housing block was built in the 1890s, the position of the pipes was switched, and so got connected up to the wrong outlets by the city. 8/n https://t.co/gJV17Vkv3S

Old Weird Scotland @WeirdScotland · Aug 25

Dr Conn took samples from the sludge traps of the 12 houses in the block and narrowed the source of the typhoid down to 2 houses (P and Q). To spare the residents embarrassment, she asked all houses to take part in a "survey" and collected samples from everyone. 9/n https://t.co/eRQ9RCUPBh

Old Weird Scotland @WeirdScotland · Aug 25

The source was a 76 year old woman who lived alone. She had never once been ill. She had never been abroad. She had lived in that house for 13 years. If not for Dr Conn and the faulty drains, she'd never have known she was an #asymptomaticcarrier of a rare Asiatic typhoid. 10/n

Old Weird Scotland @WeirdScotland · Aug 25

The carrier was identified 2 weeks before the last admitted typhoid case thanks to Dr Conn working *flat out* for 2 months. The carrier got treatment and the sewers were fixed, though they both remained positive for several months. So how did she become a healthy carrier? 11/n

Old Weird Scotland @WeirdScotland · Aug 25

Dr Conn interviewed her but, in short, nobody knows. She lived alone for most of her life, except with her father, who was a horse vet in the second Boer War and did travel afterwards. Maybe he was also an #asymptomatic carrier of Salmonella typhi K1 and she got it from him? 12/n https://t.co/vRlY5ilr1E

Old Weird Scotland @WeirdScotland · Aug 25

Nancy Conn's quick and methodical investigation stopped the outbreak of typhoid in Edinburgh. Folk stopped drinking from the Water of Leith and eventually the river got cleaned up. This photo is from the 1983 "Operation Riverbank" in Leith. 13/n https://t.co/xMqJfMChMH

Old Weird Scotland @WeirdScotland · Aug 25

Dr Agnes "Nancy" Kirkland Conn retired in 1979 and died in March 2013 aged 93. A Broughty Ferry lass, she went to Dundee High then did history and later medicine @univofstandrews. She also played hockey for Scotland. 14/14
#WomenInSTEM
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